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Issue 14, 2012
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Wound infection kinetics probed by MALDI-MS: rapid profiling of Staphylococcus aureus in mice

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Abstract

Using direct matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS), we were able to investigate the role of the clinically important bacteria, Staphylococcus aureus, in wound infections using mice. The infection kinetics of S. aureus at the wound site and the host immune response has been investigated using MALDI-MS. In this study, for the first time, we report the growth pattern of S. aureus infection at a wound site. Using mice wound infection models; the following study fingerprints the bacterial–host (mice) response at the wound site as a function of increasing wound infection in order to establish the infection pattern of Staphylococcus aureus in wounds. The current approach is extremely simple, rapid, highly selective, sensitive and established MALDI-MS as a versatile tool for detecting bacteria in clinical samples, such as those collected from wound sites.

Graphical abstract: Wound infection kinetics probed by MALDI-MS: rapid profiling of Staphylococcus aureus in mice

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Publication details

The article was received on 08 Jan 2012, accepted on 30 Apr 2012 and first published on 01 May 2012


Article type: Paper
DOI: 10.1039/C2AN35478K
Citation: Analyst, 2012,137, 3372-3380
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    Wound infection kinetics probed by MALDI-MS: rapid profiling of Staphylococcus aureus in mice

    J. L. Narayana, J. Gopal and H. Wu, Analyst, 2012, 137, 3372
    DOI: 10.1039/C2AN35478K

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