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Issue 12, 2012
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Fabrication of Co3O4 nanoparticles-decorated graphene composite for determination of L-tryptophan

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Abstract

A novel Co3O4 nanoparticles-decorated graphene (GR) composite was synthesized by electro-deposition and characterized by scanning electron micrographs, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy and transmission electron microscopy. Then, amperometric biosensors based on a Co3O4 nanoparticles-decorated GR composite modified glassy carbon electrode (GCE) were developed for the sensitive determination of L-tryptophan (Trp). The direct electrooxidation behaviors of Trp on the Co3O4/GR/Nafion/GCE were carefully investigated by cyclic voltammetry and square wave voltammetry. The results indicated that Trp showed an increase of the oxidation peak current with a negative shift of the oxidation peak potential compared with that on the bare GCE. Under optimum conditions, the proposed biosensor can be applied to the quantification analysis of Trp with a wide linear range covering 0.05–10 μM (R = 0.996) and a low detection limit of 0.01 μM. The experimental results also showed that the sensor exhibited good reproducibility, long-term stability as well as high selectivity. Moreover, the novel biosensor for the detection of Trp in a real amino acid sample with satisfactory results has been proved.

Graphical abstract: Fabrication of Co3O4 nanoparticles-decorated graphene composite for determination of l-tryptophan

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Publication details

The article was received on 07 Feb 2012, accepted on 12 Apr 2012 and first published on 13 Apr 2012


Article type: Paper
DOI: 10.1039/C2AN35175G
Citation: Analyst, 2012,137, 2840-2845
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    Fabrication of Co3O4 nanoparticles-decorated graphene composite for determination of L-tryptophan

    D. Ye, L. Luo, Y. Ding, B. Liu and X. Liu, Analyst, 2012, 137, 2840
    DOI: 10.1039/C2AN35175G

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