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Issue 8, 2012
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A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid

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Abstract

A novel chromo- and fluorogenic sensor, 4-(4-dimethylaminostyryl)-1-hexadecylpyridinium (DSHP) for lysophosphatidic acid (LPA) was successfully developed by incorporating a long alkyl chain into the cyanine molecule. DSHP shows excellent selectivity and high sensitivity towards LPA with a detection limit of about 7.09 × 10−7 M based on electrostatic and hydrophobic interactions between the sensor and LPA. Upon addition of LPA ranging from 0 to 7.5 × 10−4 M, DSHP displays an ‘on–off–on’ fluorescence response and obvious colour change. Good linear relationships between the fluorescence intensity and LPA concentrations were achieved in the fluorescence quenching ranges of 0–28 μM and 34–52 μM, which could be attributed to the combined effects of the photoinduced electron transfer and LPA-induced aggregation of the sensor molecules.

Graphical abstract: A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid

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Publication details

The article was received on 24 Nov 2011, accepted on 07 Feb 2012 and first published on 09 Mar 2012


Article type: Paper
DOI: 10.1039/C2AN16153B
Citation: Analyst, 2012,137, 1853-1859
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    A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid

    W. Zhao, W. Liu, W. Zhang, L. Zeng, Z. Fan, J. Wu and P. Wang, Analyst, 2012, 137, 1853
    DOI: 10.1039/C2AN16153B

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