Jump to main content
Jump to site search

Issue 9, 2012
Previous Article Next Article

Size-exclusion SPR sensor chip: application to detection of aggregation and disaggregation of biological particles

Author affiliations

Abstract

We propose a novel surface plasmon resonance (SPR) sensor chip with a microfabricated slit array. The microslit excludes micrometre-size objects larger than its slit size from the SPR sensing area, so that it functions as an in situ filter. We demonstrated the sensing of microparticles of different diameters using the chip, and the results show a successful size-exclusion effect. As a demonstration of the biological application, we performed the detection of aggregation and disaggregation of biological particles using sugar-chain-immobilized gold nanoparticles as a test sample.

Graphical abstract: Size-exclusion SPR sensor chip: application to detection of aggregation and disaggregation of biological particles

Back to tab navigation

Publication details

The article was received on 25 Oct 2011, accepted on 17 Feb 2012 and first published on 19 Mar 2012


Article type: Paper
DOI: 10.1039/C2AN16010B
Citation: Analyst, 2012,137, 2192-2198
  •   Request permissions

    Size-exclusion SPR sensor chip: application to detection of aggregation and disaggregation of biological particles

    K. Terao, K. Shimizu, N. Miyanishi, S. Shimamoto, T. Suzuki, H. Takao and F. Oohira, Analyst, 2012, 137, 2192
    DOI: 10.1039/C2AN16010B

Search articles by author

Spotlight

Advertisements