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Issue 18, 2011
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In situ characterization of lipidic bupivacaine-loaded formulations

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Abstract

This work details the in situ dynamical behaviour of local anaesthetic bupivacaine (BUP)-loaded L2 and H2 phase precursors (preformulations of BUP) upon rapid exposure to phosphate buffer under physiological conditions (pH 7.4, 37 °C). The hydration-induced structural transitions are characterized by time-resolved synchrotron SAXS.

Graphical abstract: In situ characterization of lipidic bupivacaine-loaded formulations

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Publication details

The article was received on 09 May 2011, accepted on 22 Jun 2011 and first published on 03 Aug 2011


Article type: Paper
DOI: 10.1039/C1SM05854A
Citation: Soft Matter, 2011,7, 8291-8295
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    In situ characterization of lipidic bupivacaine-loaded formulations

    A. Yaghmur, S. W. Larsen, M. Schmitt, J. Østergaard, C. Larsen, H. Jensen, A. Urtti and M. Rappolt, Soft Matter, 2011, 7, 8291
    DOI: 10.1039/C1SM05854A

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