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Issue 18, 2011
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Hybrid lipid/polymer giant unilamellar vesicles: effects of incorporated biocompatible PIB–PEO block copolymers on vesicle properties

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Abstract

Self-assembly of lipids and block copolymers into mixed giant unilamellar vesicles (GUVs) and the underlying phase-behavior are reported, based on the well-known assembly of natural lipids and synthetic di- and triblock copolymers in dilute solutions. In this publication the formation of mixed vesicles containing DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) and newly prepared PIB–PEO diblock copolymers (BCP) was investigated viaconfocal laser scanning microscopy and Langmuir films. Polyisobutylene (PIB) and poly(ethylene oxide) (PEO) are highly biocompatible polymers and their incorporation into DPPC vesicles therefore leads to interesting structural modifications upon the formation of hybrid GUVs. Results of the confocal microscopy studies prove the mixing/demixing behavior of lipid and polymer molecules in the corresponding bilayer membranes. In particular a homogenously mixed phase below 20 mol% and above 30 mol% of PIB87-b-PEO17, but also the formation of demixed phases of DPPC with 20 to 28 mol% of BCP were observed. Lipid/polymer interactions in mixed monolayers were further investigated by Langmuir balance techniques coupled with fluorescence microscopy. It is shown that the typical behavior of DPPC monolayers at the air/water interface is strongly disturbed by the presence of the diblock copolymers, further proving phase separation.

Graphical abstract: Hybrid lipid/polymer giant unilamellar vesicles: effects of incorporated biocompatible PIB–PEO block copolymers on vesicle properties

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Publication details

The article was received on 21 Apr 2011, accepted on 13 Jun 2011 and first published on 22 Jul 2011


Article type: Paper
DOI: 10.1039/C1SM05725A
Citation: Soft Matter, 2011,7, 8100-8110
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    Hybrid lipid/polymer giant unilamellar vesicles: effects of incorporated biocompatible PIB–PEO block copolymers on vesicle properties

    M. Schulz, D. Glatte, A. Meister, P. Scholtysek, A. Kerth, A. Blume, K. Bacia and W. H. Binder, Soft Matter, 2011, 7, 8100
    DOI: 10.1039/C1SM05725A

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