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Issue 20, 2011
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Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

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Abstract

Biological nanotubes, often referred to as tunneling nanotubes, fulfill important functions within the cell, e.g. by supplying cell components, conducting signals and transporting virus particles and bacteria. Many functions are still insufficiently understood, which has placed these nanostructures in the focus of recent investigation. We report here on our observations of transient tubulation in nanoparticle-containing, supported flat giant unilamellar vesicles (FGUVs). The encapsulation of nanoparticles in FGUVs in conjunction with low (1–4 mM) Ca2+ in the ambient buffer solution resulted in transient tube formation. Tubes extended from the FGUV up to a length of several hundred micrometres and exhibited, on some occasions, vesicle encapsulation. The findings represent an interesting confirmation of several reported theoretical and practical models of tube formation in biological or biomimetic systems.

Graphical abstract: Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

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Publication details

The article was received on 15 Apr 2011, accepted on 16 Aug 2011 and first published on 16 Sep 2011


Article type: Paper
DOI: 10.1039/C1SM05677H
Citation: Soft Matter, 2011,7, 9706-9713
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    Calcium-ion-controlled nanoparticle-induced tubulation in supported flat phospholipid vesicles

    I. Gözen, C. Billerit, P. Dommersnes, A. Jesorka and O. Orwar, Soft Matter, 2011, 7, 9706
    DOI: 10.1039/C1SM05677H

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