Issue 13, 2011
From the journal:

Soft Matter

Quantum dot-loaded PEGylated poly(alkyl cyanoacrylate) nanoparticles for in vitro and in vivo imaging†

Julien Nicolas,*a   Davide Brambilla,a   Olivier Carion,b   Thomas Pons,b   Ivan Maksimovic,b   Eric Larquet,c   Benjamin Le Droumaguet,a   Karine Andrieux,a   Benoit Dubertretb  and  Patrick Couvreura  

* Corresponding authors

a Laboratoire de Physico-Chimie, Pharmacotechnie et Biopharmacie, Univ Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, Châtenay-Malabry, France
E-mail: julien.nicolas@u-psud.fr
Fax: +33 1 46 83 59 46
Tel: +33 1 46 83 58 53

b Laboratoire Physique et Etude des Matériaux, ESPCI-CNRS-UPMC UMR 8213, 10 rue Vauquelin, Paris, France

c Institut de minéralogie et de physique des milieux condensés, Université Pierre et Marie Curie, Université Paris Diderot, CNRS UMR 7590, 4 place Jussieu, Paris, France

Abstract

Visible- and near-infrared-emitting quantum-dots (QDs) were readily encapsulated with high yields into PEGylated, poly(alkyl cyanoacrylate) nanoparticles (NPs) by self-assembly in aqueous solution. The resulting QD-loaded NPs were efficiently purified and characterized by transmission electron microscopy, dynamic light scattering and ζ-potential measurements as well as by stability studies and cell viability assays. Concomitant encapsulation of different kinds of QDs led to barcode NPs. They were then used for human brain endothelial cell imaging allowing their uptake to be monitored. Finally, the in vivo fate of near-infrared fluorescent NPs was visualized noninvasively by fluorescence optical imaging.

Graphical abstract: Quantum dot-loaded PEGylated poly(alkyl cyanoacrylate) nanoparticles for in vitro and in vivo imaging

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Supplementary files

Article information

DOI
https://doi.org/10.1039/C1SM05529A
Article type
Paper
Submitted
28 Mar 2011
Accepted
03 May 2011
First published
27 May 2011

Soft Matter, 2011,7, 6187-6193

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Quantum dot-loaded PEGylated poly(alkyl cyanoacrylate) nanoparticles for in vitro and in vivo imaging

J. Nicolas, D. Brambilla, O. Carion, T. Pons, I. Maksimovic, E. Larquet, B. Le Droumaguet, K. Andrieux, B. Dubertret and P. Couvreur, Soft Matter, 2011, 7, 6187 DOI: 10.1039/C1SM05529A

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