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Issue 11, 2011
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Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

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Abstract

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.

Graphical abstract: Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

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Publication details

The article was received on 23 Feb 2011, accepted on 02 Apr 2011 and first published on 05 May 2011


Article type: Paper
DOI: 10.1039/C1SM05324H
Citation: Soft Matter, 2011,7, 5417-5422
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    Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

    D. Lensen, E. C. Gelderblom, D. M. Vriezema, P. Marmottant, N. Verdonschot, M. Versluis, N. de Jong and J. C. M. van Hest, Soft Matter, 2011, 7, 5417
    DOI: 10.1039/C1SM05324H

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