Issue 10, 2011
From the journal:

Soft Matter

Unidirectional mechanical cellular stimuli via micropost array gradients†

Ryan D. Sochol,*a   Adrienne T. Higa,a   Randall R. R. Janairo,b   Song Lib  and  Liwei Lina  

* Corresponding authors

a Berkeley Sensor and Actuator Center, Department of Mechanical Engineering, University of California, Berkeley, 668 Sutardja Dai Hall, Berkeley, CA, USA
E-mail: rsochol@gmail.com

b Department of Bioengineering, University of California, Berkeley, and UC Berkeley-UCSF Bioengineering Graduate Program, CA, USA

Abstract

Diverse cellular processes are influenced by the mechanical properties of the substrate. Here we introduce the methodology of constructing micropost array gradients to investigate the effects of unidirectional substrate stiffness cues on living cells. Experimental results revealed preferential cell migration in the direction of increasing micropost stiffness.

Graphical abstract: Unidirectional mechanical cellular stimuli via micropost array gradients

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Article information

DOI
https://doi.org/10.1039/C1SM05163F
Article type
Communication
Submitted
31 Jan 2011
Accepted
09 Mar 2011
First published
24 Mar 2011

Soft Matter, 2011,7, 4606-4609

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Unidirectional mechanical cellular stimuli via micropost array gradients

R. D. Sochol, A. T. Higa, R. R. R. Janairo, S. Li and L. Lin, Soft Matter, 2011, 7, 4606 DOI: 10.1039/C1SM05163F

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