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Issue 9, 2011
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Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids

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Abstract

Soft and spherical nanoparticles, named as cutinsomes, have been prepared from concentrated 9(10),16-dihydroxypalmitic acid (diHPA) in aqueous solution. After isolation, cutinsomes have been chemically and structurally characterized by ATR-FTIR, TEM and dynamic atomic force microscopy (dynamic AFM). The nanoparticle can be described as a lipidic, liquid-like and mostly esterified core surrounded by a polar shell of carboxylate/carboxylic acid molecules. Molecular dynamic (MD) simulations have been used to support this model. The structural stability of soft cutinsomes has been tested by deposition on both non-polar (HOPG) and polar (mica) flat substrates. It has been found that the magnitude of the interaction between the polar shell of cutinsomes and the support determines their structure conservation or its spreading or rupture and spill out of the liquid-like content. The structural consistence of these nanoparticles as a function of the polarity of substrate is of interest in elucidating the formation mechanism of cutin, the most abundant biopolyester in nature and a very interesting biomaterial to be mimetized.

Graphical abstract: Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids

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Publication details

The article was received on 25 Dec 2010, accepted on 15 Feb 2011 and first published on 10 Mar 2011


Article type: Paper
DOI: 10.1039/C0SM01545H
Citation: Soft Matter, 2011,7, 4357-4363
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    Structure and support induced structure disruption of soft nanoparticles obtained from hydroxylated fatty acids

    J. A. Heredia-Guerrero, M. A. San-Miguel, M. Luna, E. Domínguez, A. Heredia and J. J. Benítez, Soft Matter, 2011, 7, 4357
    DOI: 10.1039/C0SM01545H

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