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Issue 8, 2011
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Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

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Abstract

Water soluble poly(hydroxyethyl acrylate) [P(HEA)] polymers were successfully conjugated to an azide functionalized β-sheet forming peptide (P11-2) to form macromolecular chimeras using Cu(I) catalyzed azide–alkyne cycloaddition (‘click’) chemistry. We found that the β-sheet formation and hence fibrillization tendency of P11-2 was severely diminished by P(HEA) conjugation. Moreover chimeras were observed to inhibit fibrillization when added to a pure β-sheet forming peptide.

Graphical abstract: Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

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Publication details

The article was received on 31 Oct 2010, accepted on 24 Feb 2011 and first published on 11 Mar 2011


Article type: Communication
DOI: 10.1039/C0SM01237H
Citation: Soft Matter, 2011,7, 3754-3757
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    Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

    H. Kakwere, R. J. Payne, K. A. Jolliffe and S. Perrier, Soft Matter, 2011, 7, 3754
    DOI: 10.1039/C0SM01237H

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