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Issue 5, 2011
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Facile growth factor immobilization platform based on engineered phage matrices

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Abstract

Immobilized growth factors on tissue matrices play a critical role in controlling cell growth processes and cell morphology. We report a strategy for immobilizing growth factors on genetically engineered phage matrices for tissue regeneration. We modified M13 phages to express biotin-like peptides (HPQ) and/or integrin binding peptides (RGD) on their major and minor coat proteins. The resulting phages formed nanofibrous matrices that could easily immobilize growth factors FGFb and NGF. We demonstrated the synergistic roles of the growth factors and integrin binding peptides in controlling cell morphologies and growth. Our phage matrices, which can be easily functionalized with various ligands and growth factors, can be used as a convenient test bed for investigating the functions of various biochemical stimulants of numerous cell types.

Graphical abstract: Facile growth factor immobilization platform based on engineered phage matrices

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Publication details

The article was received on 27 Oct 2010, accepted on 14 Dec 2010 and first published on 20 Jan 2011


Article type: Communication
DOI: 10.1039/C0SM01220C
Citation: Soft Matter, 2011,7, 1660-1666
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    Facile growth factor immobilization platform based on engineered phage matrices

    S. Y. Yoo, A. Merzlyak and S. Lee, Soft Matter, 2011, 7, 1660
    DOI: 10.1039/C0SM01220C

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