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Issue 13, 2011
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pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism

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Abstract

Alginate hydrogels containing biocompatible Laponite (LP) were prepared and dried under vacuum or in an oven, and their drug release properties at different pH values were studied in vitro using methylene blue (MB) as a model of a cationic drug. These hybrid hydrogels showed a greater encapsulation efficiency of MB, a better sustained release and higher pH sensitivity in MB release, compared to the pure AG gels. The oven-dried hybrid gels were more pH sensitive in MB release than the vacuum-dried ones. Furthermore, the presence of LP, the drying mode and the pH value were shown to influence the mechanism of MB release. LP/AG hybrid gels are, thus, good candidates for the controlled delivery of cationic drugs under acidic conditions.

Graphical abstract: pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism

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Publication details

The article was received on 25 Feb 2011, accepted on 03 May 2011 and first published on 02 Jun 2011


Article type: Paper
DOI: 10.1039/C1SM05345K
Citation: Soft Matter, 2011,7, 6231-6238
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    pH sensitive Laponite/alginate hybrid hydrogels: swelling behaviour and release mechanism

    Y. Li, D. Maciel, H. Tomás, J. Rodrigues, H. Ma and X. Shi, Soft Matter, 2011, 7, 6231
    DOI: 10.1039/C1SM05345K

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