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Issue 12, 2011
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Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

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Abstract

A general and efficient condition for palladium-catalyzed Heck alkynylation in batch was developed using a novel precatalyst. In addition, the first general and efficient continuous-flow protocol for the coupling of alkynes with aryl bromides in the absence of copper was reported.

Graphical abstract: Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

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Publication details

The article was received on 28 Jun 2011, accepted on 22 Aug 2011 and first published on 07 Sep 2011


Article type: Edge Article
DOI: 10.1039/C1SC00409C
Citation: Chem. Sci., 2011,2, 2321-2325
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    Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

    W. Shu and S. L. Buchwald, Chem. Sci., 2011, 2, 2321
    DOI: 10.1039/C1SC00409C

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