Issue 4, 2011

Chemoselective enrichment for natural products discovery

Abstract

Natural products account for a significant proportion of modern day therapeutic agents. However, the discovery of novel compounds is hindered by the isolation process, which often relies upon extraction and chromatographic separation techniques. These methods, which are dependent upon the physicochemical properties of the compounds, have a limited ability to both purify and concentrate the minor components of a biological extract. We have devised an isolation strategy based upon an orthogonal chemical feature, namely, functional group composition. Development of a functional group-targeted method is expected to achieve exceptional resolution given the large number of distinct moieties present in natural product extracts. Here, we describe the generation of controllably reversible covalent enrichment tags for the chemoselective isolation of alcohol-containing natural products from complex mixtures.

Graphical abstract: Chemoselective enrichment for natural products discovery

Supplementary files

Article information

Article type
Edge Article
Submitted
11 Dec 2010
Accepted
06 Jan 2011
First published
28 Jan 2011

Chem. Sci., 2011,2, 760-764

Chemoselective enrichment for natural products discovery

A. Y. Odendaal, D. J. Trader and E. E. Carlson, Chem. Sci., 2011, 2, 760 DOI: 10.1039/C0SC00620C

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