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Issue 1, 2012
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A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

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Abstract

A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.

Graphical abstract: A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

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Publication details

The article was received on 11 Aug 2011, accepted on 06 Sep 2011, published on 22 Sep 2011 and first published online on 22 Sep 2011


Article type: Edge Article
DOI: 10.1039/C1SC00556A
Citation: Chem. Sci., 2012,3, 58-61
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    A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

    S. P. Simonovich, J. F. Van Humbeck and D. W. C. MacMillan, Chem. Sci., 2012, 3, 58
    DOI: 10.1039/C1SC00556A

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