Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 1, 2012
Previous Article Next Article

A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

Author affiliations

Abstract

A new enantioselective α-oxidation of aldehydes has been accomplished using TEMPO and a synergistic combination of copper and organic catalysis. Expanding upon recently reported mechanistic studies, these mild catalytic conditions provide stable aldehyde products bearing a wide array of electronically and sterically diverse substructures. The utility of these oxidized products is highlighted by subsequent derivatization to a variety of common chiral synthons, without loss in enantiopurity.

Graphical abstract: A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 11 Aug 2011, accepted on 06 Sep 2011 and first published on 22 Sep 2011


Article type: Edge Article
DOI: 10.1039/C1SC00556A
Citation: Chem. Sci., 2012,3, 58-61
  •   Request permissions

    A general approach to the enantioselective α-oxidation of aldehydesvia synergistic catalysis

    S. P. Simonovich, J. F. Van Humbeck and D. W. C. MacMillan, Chem. Sci., 2012, 3, 58
    DOI: 10.1039/C1SC00556A

Search articles by author