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Issue 2, 2011
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A supramolecular route for reversible protein-polymer conjugation

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The supramolecular formation of a PEGylated bovine serum albumin (BSA) protein-polymer bio-conjugate in water has been demonstrated through a selective host–guest interaction with the macrocycle cucurbit[8]uril (CB[8]). Both BSA and poly(ethylene glycol) were functionalised with either an electron-deficient first guest viologen or an electron-rich second guest naphthalene for the formation of the CB[8] ternary complex. With the help of spectroscopic (NMR, DOSY-NMR, DLS, UV/vis, fluorescence) and calorimetric (ITC) techniques, it was shown that a strong and specific binding interaction took place between the complementary labeled polymer and protein only in the presence of the macrocyclic host CB[8]. Moreover, we demonstrated that controlled formation of a supramolecular protein-protein complex was also possible through the use of CB[8] ternary formation.

Graphical abstract: A supramolecular route for reversible protein-polymer conjugation

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The article was received on 13 Aug 2010, accepted on 17 Sep 2010 and first published on 18 Oct 2010

Article type: Edge Article
DOI: 10.1039/C0SC00435A
Citation: Chem. Sci., 2011,2, 279-286
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    A supramolecular route for reversible protein-polymer conjugation

    F. Biedermann, U. Rauwald, J. M. Zayed and O. A. Scherman, Chem. Sci., 2011, 2, 279
    DOI: 10.1039/C0SC00435A

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