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Issue 5, 2011
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Radiopaque iodinated nano-emulsions for preclinical X-ray imaging

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Abstract

The context of the this research is the development of nanoparticulate systems exhibiting long circulation times in the blood pool, loaded with X-ray contrasting compounds, to be used as blood pool contrast agents in computed tomography. This study presents an original, new and simple formulation of radiopaque nano-emulsions composed of iodinated oil, formed by a spontaneous emulsification method. As a result, extremely monodisperse, iodinated nano-droplets were generated, ranging in size from 20 to 190 nm, presenting an iodine concentration of around 85 mg I/mL, and coated with a polyethylene glycol shell which ensured their stealth properties against the immune system in the blood stream. In vivo assays demonstrated a significant contrast effect, along with a long residence in the blood pool. This study highlights novel nano-formulations used as efficient contrast agents for preclinical X-ray imaging applications, along with simple and efficient alternatives for the generation of iodinated nano-emulsions.

Graphical abstract: Radiopaque iodinated nano-emulsions for preclinical X-ray imaging

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Publication details

The article was received on 15 Apr 2011, accepted on 20 Jul 2011 and first published on 25 Aug 2011


Article type: Paper
DOI: 10.1039/C1RA00048A
Citation: RSC Adv., 2011,1, 792-801
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    Radiopaque iodinated nano-emulsions for preclinical X-ray imaging

    F. Hallouard, N. Anton, G. Zuber, P. Choquet, X. Li, Y. Arntz, G. Aubertin, A. Constantinesco and T. F. Vandamme, RSC Adv., 2011, 1, 792
    DOI: 10.1039/C1RA00048A

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