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Issue 6, 2011
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Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide

Yoshihiro Sasaki,ab  Yuji Tsuchido,a  Shin-ichi Sawadaa  and  Kazunari Akiyoshi*ac 
Author affiliations

* Corresponding authors

a Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo, Japan
Fax: +81-3-5280-8027
Tel: +81-3-5280-8026

b PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama, Japan

c Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto, Japan
E-mail: akiyoshi@bio.polym.kyoto-u.ac.jp
Fax: +81-75-383-2589
Tel: +81-75-383-2590

Abstract

Protein-crosslinked nanogels were prepared by introducing vitamin B6 (pyridoxal) to hydrophilic polysaccharide. The pH dependence of Schiff base formation was utilized to generate a pH-sensitive nanogel system. This approach represents a new method to prepare hybrid nanogels crosslinked with biomolecules.

Graphical abstract: Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide

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Publication details

The article was received on 05 Mar 2011, accepted on 07 Apr 2011 and first published on 28 Apr 2011


Article type: Communication
DOI: 10.1039/C1PY00100K
Citation: Polym. Chem., 2011,2, 1267-1270
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    Construction of protein-crosslinked nanogels with vitamin B6 bearing polysaccharide

    Y. Sasaki, Y. Tsuchido, S. Sawada and K. Akiyoshi, Polym. Chem., 2011, 2, 1267
    DOI: 10.1039/C1PY00100K

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