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Issue 4, 2011
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Self-immolative linkers in polymeric delivery systems

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There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics. The advancement in novel substrate-polymer coupling moieties has led to the discovery of self-immolative linkers. This new class of linker has gained popularity in recent years in polymeric release technology as a result of stable bond formation between protecting and leaving groups, which becomes labile upon activation, leading to the rapid disassembly of the parent polymer. This ability has prompted numerous studies into the design and development of self-immolative linkers and the kinetics surrounding their disassembly. This review details the main concepts that underpin self-immolative linker technologies that feature in polymeric or dendritic conjugate systems and outlines the chemistries of amplified self-immolative elimination.

Graphical abstract: Self-immolative linkers in polymeric delivery systems

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Publication details

The article was received on 28 Sep 2010, accepted on 30 Oct 2010 and first published on 18 Nov 2010

Article type: Review Article
DOI: 10.1039/C0PY00324G
Citation: Polym. Chem., 2011,2, 773-790
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    Self-immolative linkers in polymeric delivery systems

    C. A. Blencowe, A. T. Russell, F. Greco, W. Hayes and D. W. Thornthwaite, Polym. Chem., 2011, 2, 773
    DOI: 10.1039/C0PY00324G

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