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Issue 3, 2011
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Shedding the hydrophilic mantle of polymersomes

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Block copolymers of polybutadiene-b-poly(ethylene glycol) were prepared in which both segments were coupled via an acid sensitive hydrazone moiety. Polymersomes that were subsequently formed showed a strong pH-dependent colloidal stability as a result of the pH sensitive removal of the PEG block. By mixing this stimulus responsive block polymer with an inert analogue it was possible to systematically remove percentages of PEG from the polymersome mantle. The minimum amount of surface PEGylation needed to retain stable polymersomes was found to be as low as five percent.

Graphical abstract: Shedding the hydrophilic mantle of polymersomes

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The article was received on 23 Sep 2010, accepted on 26 Oct 2010 and first published on 16 Nov 2010

Article type: Communication
DOI: 10.1039/C0PY00316F
Citation: Polym. Chem., 2011,2, 550-552
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    Shedding the hydrophilic mantle of polymersomes

    R. P. Brinkhuis, T. R. Visser, F. P. J. T. Rutjes and J. C. M. van Hest, Polym. Chem., 2011, 2, 550
    DOI: 10.1039/C0PY00316F

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