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Issue 2, 2011
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Linear dendritic polymeric amphiphiles with intrinsic biocompatibility: synthesis and characterization to fabrication of micelles and honeycomb membranes

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Abstract

Linear dendritic hybrid materials enable a range of architectural variations which offers novel possibilities in the tailoring of polymeric materials. In this study dendrons based on the 2,2-bis(methylol)propionic acid (bis-MPA) building block, bearing click chemistry moieties in the core and peripheral hydroxyl functionalities, have been used as macroinitiators for ring opening polymerization of ε-caprolactone. A library of star branched polymers with poly(ε-caprolactone) chains was initially constructed using dendrons up to 4th generation. In a second step, the popular CuAAC or thiol–ene click reaction was efficiently used to attach poly(ethylene glycol) chains of different lengths to the core. Potential applications of the resulted amphiphilic linear dendritic hybrids were investigated. Both self-assembled micelles loaded with doxorubicin anticancer drug and ordered honeycomb membranes with enhanced surface area were successfully fabricated and characterized.

Graphical abstract: Linear dendritic polymeric amphiphiles with intrinsic biocompatibility: synthesis and characterization to fabrication of micelles and honeycomb membranes

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Publication details

The article was received on 11 Aug 2010, accepted on 22 Sep 2010 and first published on 18 Oct 2010


Article type: Paper
DOI: 10.1039/C0PY00258E
Citation: Polym. Chem., 2011,2, 394-402
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    Linear dendritic polymeric amphiphiles with intrinsic biocompatibility: synthesis and characterization to fabrication of micelles and honeycomb membranes

    P. Lundberg, M. V. Walter, M. I. Montañez, D. Hult, A. Hult, A. Nyström and M. Malkoch, Polym. Chem., 2011, 2, 394
    DOI: 10.1039/C0PY00258E

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