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Issue 2, 2011
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Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

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Abstract

Reversible addition–fragmentation chain transfer (RAFT) of N-isopropylacrylamide with a chain transfer agent containing an activated-ester moiety was employed to prepare well-defined temperature-responsive polymers for conjugation to amine-containing proteins. Bioconjugation efficiency of the polymers with lysozyme was investigated as a function of stoichiometry, polymer molecular weight, and reaction pH. The resulting polymerprotein conjugates retained the temperature-responsive nature of the original polymers.

Graphical abstract: Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

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Publication details

The article was received on 10 Jun 2010, accepted on 06 Jul 2010 and first published on 31 Aug 2010


Article type: Paper
DOI: 10.1039/C0PY00178C
Citation: Polym. Chem., 2011,2, 323-327
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    Protein conjugation of thermoresponsive amine-reactive polymers prepared by RAFT

    H. Li, A. P. Bapat, M. Li and B. S. Sumerlin, Polym. Chem., 2011, 2, 323
    DOI: 10.1039/C0PY00178C

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