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Issue 5, 2011
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Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyaninegold nanoparticle conjugates

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Abstract

A 4-component antibody–phthalocyanine–polyethylene glycol–gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc–phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticlesvia a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.

Graphical abstract: Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

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Publication details

The article was received on 11 Jan 2011, accepted on 07 Mar 2011 and first published on 01 Apr 2011


Article type: Paper
DOI: 10.1039/C1PP05014A
Citation: Photochem. Photobiol. Sci., 2011,10, 822-831
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    Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyaninegold nanoparticle conjugates

    T. Stuchinskaya, M. Moreno, M. J. Cook, D. R. Edwards and D. A. Russell, Photochem. Photobiol. Sci., 2011, 10, 822
    DOI: 10.1039/C1PP05014A

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