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Issue 7, 2011
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Photodynamic therapy and two-photon bio-imaging applications of hydrophobic chromophores through amphiphilic polymer delivery

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Abstract

The synthesis and photophysical properties of two lipophilic quadrupolar chromophores featuring anthracenyl (1) or dibromobenzene (2) were described. These two chromophores combined significant two-photon absorption cross-sections with high fluorescence quantum yield for 1 and improved singlet oxygen generation efficiency for 2, in organic solvents. The use of Pluronic nanoparticles allowed a simple and straightforward introduction of these lipophilic chromophores into biological cell media. Their internal distribution in various cell lines was studied using fluorescence microscopy and flow-cytometry following a successful staining that was achieved upon 2 h of incubation. Finally, multiphoton excitation microscopy and photodynamic therapy capability of the chromophores were demonstrated by cell exposure to a 820 nm fs laser and cell death upon one photon resonant irradiation at 436 ± 10 nm, respectively.

Graphical abstract: Photodynamic therapy and two-photon bio-imaging applications of hydrophobic chromophores through amphiphilic polymer delivery

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Publication details

The article was received on 16 Dec 2010, accepted on 21 Feb 2011 and first published on 18 Apr 2011


Article type: Paper
DOI: 10.1039/C0PP00381F
Citation: Photochem. Photobiol. Sci., 2011,10, 1216-1225
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    Photodynamic therapy and two-photon bio-imaging applications of hydrophobic chromophores through amphiphilic polymer delivery

    T. Gallavardin, M. Maurin, S. Marotte, T. Simon, A. Gabudean, Y. Bretonnière, M. Lindgren, F. Lerouge, P. L. Baldeck, O. Stéphan, Y. Leverrier, J. Marvel, S. Parola, O. Maury and C. Andraud, Photochem. Photobiol. Sci., 2011, 10, 1216
    DOI: 10.1039/C0PP00381F

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