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Issue 5, 2011
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Photodynamic therapy enhancement of anti-tumor immunity

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Abstract

Photodynamic therapy (PDT) is an FDA-approved modality for the treatment of early-stage disease and palliation of late-stage disease. Pre-clinical studies using mouse models and clinical studies in patients have demonstrated that PDT is capable of influencing the immune system. The effect of PDT on the generation of anti-tumor immunity is regimen-dependent and is tightly linked to the degree and nature of inflammation induced by PDT. However, the precise mechanism underlying PDT-regulated adaptive anti-tumor immunity remains unclear. This review will focus on the current knowledge of immune regulation by PDT.

Graphical abstract: Photodynamic therapy enhancement of anti-tumor immunity

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Publication details

The article was received on 22 Nov 2010, accepted on 12 Dec 2010 and first published on 21 Jan 2011


Article type: Perspective
DOI: 10.1039/C0PP00354A
Citation: Photochem. Photobiol. Sci., 2011,10, 649-652
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    Photodynamic therapy enhancement of anti-tumor immunity

    C. M. Brackett and S. O. Gollnick, Photochem. Photobiol. Sci., 2011, 10, 649
    DOI: 10.1039/C0PP00354A

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