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Issue 5, 2011
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Clinical and immunological response to photodynamic therapy in the treatment of vulval intraepithelial neoplasia

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Abstract

Vulval intraepithelial neoplasia (VIN) is a premalignant condition of the vulva and its incidence is increasing. The common type of VIN is associated with oncogenic types of human papilloma virus (HPV) infection. The standard modalities of treatment for VIN, surgical excision and laser ablation, are both sub-optimal, associated with high rates of disease recurrence. There is a need for non-surgical treatment options for VIN and photodynamic therapy (PDT), by altering the local immunological parameters, has the potential to clear both VIN and HPV. This article reviews the studies of PDT treatment for VIN and discusses the clinical and immunological responses to PDT treatment in the various studies.

Graphical abstract: Clinical and immunological response to photodynamic therapy in the treatment of vulval intraepithelial neoplasia

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Publication details

The article was received on 14 Nov 2010, accepted on 20 Jan 2011 and first published on 14 Apr 2011


Article type: Perspective
DOI: 10.1039/C0PP00344A
Citation: Photochem. Photobiol. Sci., 2011,10, 802-809
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    Clinical and immunological response to photodynamic therapy in the treatment of vulval intraepithelial neoplasia

    S. Daayana, U. Winters, P. L. Stern and H. C. Kitchener, Photochem. Photobiol. Sci., 2011, 10, 802
    DOI: 10.1039/C0PP00344A

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