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Issue 6, 2011
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Tumour cell death induced by the bulk photovoltaic effect of LiNbO3:Fe under visible light irradiation

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Abstract

This work reports a pioneer application of the bulk photovoltaic effect in the biomedical field. Massive necrotic cell death was induced in human tumour cell cultures grown on a bulk photovoltaic material (iron-doped lithium niobate, LiNbO3:Fe) after irradiation with visible light. Lethal doses (≈100% cell death) were obtained with low-intensity visible light sources (10–100 mW cm−2 irradiances) and short exposure times of the order of minutes. The wavelength dependence to induce the lethal effect observed is consistent with that corresponding to the bulk photovoltaic effect generation in LiNbO3:Fe. Necrosis also occurred when cultured tumour cells were exposed to LiNbO3:Fe microparticles and visible light.

Graphical abstract: Tumour cell death induced by the bulk photovoltaic effect of LiNbO3:Fe under visible light irradiation

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Publication details

The article was received on 10 Nov 2010, accepted on 26 Jan 2011 and first published on 19 Feb 2011


Article type: Paper
DOI: 10.1039/C0PP00336K
Citation: Photochem. Photobiol. Sci., 2011,10, 956-963
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    Tumour cell death induced by the bulk photovoltaic effect of LiNbO3:Fe under visible light irradiation

    A. Blázquez-Castro, J. C. Stockert, B. López-Arias, A. Juarranz, F. Agulló-López, A. García-Cabañes and M. Carrascosa, Photochem. Photobiol. Sci., 2011, 10, 956
    DOI: 10.1039/C0PP00336K

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