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Issue 5, 2011
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Photosensitiser–antibody conjugates for photodynamic therapy

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Abstract

Research into targeting of photodynamic sensitisers to specific biological tissue has been an area of increasing interest over the last twenty years. A significant number of these investigations have involved the use of antibodies or antibody fragments, and the field of photosensitiser bioconjugation is now an established area in its own right. This review seeks to bring together the diverse range of methodology now available for the efficient attachment of photodynamic agents to antibodies. The chemistry involved to obtain the complementary functionality required, on both photosensitiser and antibody, for successful conjugation is also discussed.

Graphical abstract: Photosensitiser–antibody conjugates for photodynamic therapy

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Publication details

The article was received on 27 Aug 2010, accepted on 26 Jan 2011 and first published on 15 Mar 2011


Article type: Perspective
DOI: 10.1039/C0PP00266F
Citation: Photochem. Photobiol. Sci., 2011,10, 721-750
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    Photosensitiser–antibody conjugates for photodynamic therapy

    A. J. Bullous, C. M. A. Alonso and R. W. Boyle, Photochem. Photobiol. Sci., 2011, 10, 721
    DOI: 10.1039/C0PP00266F

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