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Issue 21, 2011
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Exploring isonitrile-based click chemistry for ligation with biomolecules

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Abstract

We show here that isonitriles can perform click reactions with tetrazines in aqueous media, making them promising candidates for ligation reactions in chemical biology and polymer chemistry. This is the first time that a [4+1] cycloaddition has been used as a biocompatible ligation reaction.

Graphical abstract: Exploring isonitrile-based click chemistry for ligation with biomolecules

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Publication details

The article was received on 19 Aug 2011, accepted on 24 Aug 2011 and first published on 25 Aug 2011


Article type: Communication
DOI: 10.1039/C1OB06424J
Citation: Org. Biomol. Chem., 2011,9, 7303-7305
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    Exploring isonitrile-based click chemistry for ligation with biomolecules

    H. Stöckmann, A. A. Neves, S. Stairs, K. M. Brindle and F. J. Leeper, Org. Biomol. Chem., 2011, 9, 7303
    DOI: 10.1039/C1OB06424J

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