Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Peter Koos; Ulrike Gross; Anastasios Polyzos; Matthew O'Brien; Ian Baxendale; Steven V. Ley

doi:10.1039/C1OB06017A

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Organic & Biomolecular Chemistry

Issue 20, 2011

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Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

Peter Koos , Ulrike Gross , Anastasios Polyzos , Matthew O'Brien , Ian Baxendale and Steven V. Ley

Org. Biomol. Chem., 2011, 9, 6903-6908

DOI: 10.1039/C1OB06017A
Received 25 Jun 2011, Accepted 27 Jul 2011
First published on the web 27 Jul 2011

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Abstract
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We report on the development of a continuous flow process for the palladium catalysed methoxycarbonylation of aryl, heteroaromatic and vinyl iodides and an aryl bromide using a Teflon AF-2400 based Tube-in-Tube reactor to mediate the selective permeation of carbon monoxide into solution at elevated pressures. The low volume of pressurised gas within the reactor (5.6 mL) offers the potential for an enhanced safety profile compared to batch processes. We also present preliminary results for the use of in situ FTIR to measure solution concentrations of carbon monoxide and demonstrate the use of a second reactor to effect the removal of carbon monoxide from the flow stream.

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Articles By

Peter Koos
Ulrike Gross
Anastasios Polyzos
Matthew O'Brien
Ian Baxendale
Steven V. Ley

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Organic & Biomolecular Chemistry

Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

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