Issue 18, 2011
From the journal:

Organic & Biomolecular Chemistry

Copper-catalyzed, aerobic oxidative cross-coupling of alkynes with arylboronic acids: remarkable selectivity in 2,6-lutidine media†‡

Tomohiro Yasukawa,a   Hiroyuki Miyamuraa  and  Shū Kobayashi*a  

* Corresponding authors

a Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan
E-mail: shu_kobayashi@chem.s.u-tokyo.ac.jp

Abstract

Aerobic oxidative cross-coupling reactions between alkynes and boronic acids under mild conditions catalyzed by low loadings of a copper salt are reported. 2,6-Lutidine accelerated the reactions dramatically, and the desired coupling products were obtained in high yields with high selectivities.

Graphical abstract: Copper-catalyzed, aerobic oxidative cross-coupling of alkynes with arylboronic acids: remarkable selectivity in 2,6-lutidine media

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Article information

DOI
https://doi.org/10.1039/C1OB05915G
Article type
Communication
Submitted
07 Jun 2011
Accepted
08 Jul 2011
First published
08 Jul 2011

Org. Biomol. Chem., 2011,9, 6208-6210

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Copper-catalyzed, aerobic oxidative cross-coupling of alkynes with arylboronic acids: remarkable selectivity in 2,6-lutidine media

T. Yasukawa, H. Miyamura and S. Kobayashi, Org. Biomol. Chem., 2011, 9, 6208 DOI: 10.1039/C1OB05915G

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