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Issue 19, 2011
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Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

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Abstract

A prototype tube-in-tube reactor in which it is possible to load gas and heat simultaneously has been used in a continuous-flow approach to alkoxycarbonylation reactions of aryl iodides. In the stainless steel coil, liquid flows on the outside of a gas-permeable membrane. The coil can be heated and the temperature can be measured accurately via a probe touching the outer steel surface. A range of aryl iodides can be transformed to the corresponding esters in excellent conversion by reaction at 120 °C using 0.5 mol% palladium acetate as the catalyst with no additional ligand required. Small-scale optimization and substrate screening runs were followed by scale-up.

Graphical abstract: Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

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Publication details

The article was received on 23 May 2011, accepted on 01 Jul 2011 and first published on 17 Aug 2011


Article type: Paper
DOI: 10.1039/C1OB05808H
Citation: Org. Biomol. Chem., 2011,9, 6575-6578
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    Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously

    M. A. Mercadante and N. E. Leadbeater, Org. Biomol. Chem., 2011, 9, 6575
    DOI: 10.1039/C1OB05808H

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