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Issue 19, 2011
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γ-AApeptides bind to RNA by mimicking RNA-binding proteins

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Abstract

The interactions between proteins and RNAs are of vital importance for many cellular processes, including transcription and processing of RNA, translation, and viral infections. Here we report an γ-AApeptide that can mimic HIV-1 Tat protein and bind to TAR RNAs of HIV and BIV with nanomolar affinity, comparable to that of the RNA-binding fragment of Tat (amino acids 49–58). The interaction is resistant to the presence of a large excess of tRNA. With resistance to proteolytic hydrolysis and limitless potential for diversification, γ-AApeptides may emerge as a new class of peptidomimetics to modulate RNA-protein interactions.

Graphical abstract: γ-AApeptides bind to RNA by mimicking RNA-binding proteins

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Publication details

The article was received on 11 May 2011, accepted on 01 Jul 2011 and first published on 01 Jul 2011


Article type: Paper
DOI: 10.1039/C1OB05738C
Citation: Org. Biomol. Chem., 2011,9, 6604-6609
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    γ-AApeptides bind to RNA by mimicking RNA-binding proteins

    Y. Niu, A. “. Jones, H. Wu, G. Varani and J. Cai, Org. Biomol. Chem., 2011, 9, 6604
    DOI: 10.1039/C1OB05738C

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