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Issue 15, 2011
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A rapid and convergent synthesis of the integrastatin core

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Abstract

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

Graphical abstract: A rapid and convergent synthesis of the integrastatin core

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Publication details

The article was received on 08 May 2011, accepted on 26 May 2011 and first published on 26 May 2011


Article type: Communication
DOI: 10.1039/C1OB05725A
Citation: Org. Biomol. Chem., 2011,9, 5354-5357
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    A rapid and convergent synthesis of the integrastatin core

    P. M. Tadross, P. Bugga and B. M. Stoltz, Org. Biomol. Chem., 2011, 9, 5354
    DOI: 10.1039/C1OB05725A

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