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Issue 15, 2011
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Molecular dynamics simulations of the Salmonella typhiVi antigenic polysaccharide and effects of the introduction of a zwitterionic motif

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Abstract

A series of hexasaccharides corresponding to the Vi capsular polysaccharide, a polymer of α-(1→4)-galacturonic acid, and analogs containing a zwitterionic motif with various degrees of acetylation at positions 3 have been modeled. When submitted to molecular dynamics simulations in a water box, all the structures visited only two quite restricted regions of the ϕ/ψ conformational space both corresponding to extended geometries without any tendency towards supercoiling. The most stable conformation showed a clockwise helix arrangement of substituents on the molecular surface whereas the opposite arrangement was observed for the other conformation. The flexibility of the system and the hydrophobic character of the molecular surface are modulated by the 3-O-acetyl groups that confer rigidity to the system. In the zwitterionic analogs, the introduction of positive charges in the place of the acetamido groups alters the hydrophobicity that can be regained by methylation of the amino groups. The needed molecular flexibility can be obtained by the complete deacetylation at positions 3.

Graphical abstract: Molecular dynamics simulations of the Salmonella typhiVi antigenic polysaccharide and effects of the introduction of a zwitterionic motif

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Publication details

The article was received on 18 Apr 2011, accepted on 13 May 2011 and first published on 13 May 2011


Article type: Paper
DOI: 10.1039/C1OB05617D
Citation: Org. Biomol. Chem., 2011,9, 5554-5559
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    Molecular dynamics simulations of the Salmonella typhiVi antigenic polysaccharide and effects of the introduction of a zwitterionic motif

    L. Legnani, F. Compostella, G. Grazioso, F. M. Albini and L. Toma, Org. Biomol. Chem., 2011, 9, 5554
    DOI: 10.1039/C1OB05617D

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