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Issue 13, 2011
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Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

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Abstract

Malaitasterol A, an unprecedented bis-secosterol, was isolated from a Solomon collection of Theonella swinhoei. The structure was elucidated on the basis of a combination of comprehensive 1D and 2D NMR analysis, high-resolution mass spectrometry and DFT 13C chemical shift calculations. The biological characterization of malaitasterol A provided evidence that this compound is a potent agonist of pregnane-X-receptor and its putative binding mode to PXR has been obtained through docking calculations.

Graphical abstract: Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

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Publication details

The article was received on 10 Mar 2011, accepted on 08 Apr 2011 and first published on 11 Apr 2011


Article type: Paper
DOI: 10.1039/C1OB05378G
Citation: Org. Biomol. Chem., 2011,9, 4856-4862
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    Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

    S. De Marino, V. Sepe, M. V. D'Auria, G. Bifulco, B. Renga, S. Petek, S. Fiorucci and A. Zampella, Org. Biomol. Chem., 2011, 9, 4856
    DOI: 10.1039/C1OB05378G

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