Issue 15, 2011
From the journal:

Organic & Biomolecular Chemistry

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells†

Jiří Paleček,a   Robert Zweigerdt,b   Ruth Olmer,b   Ulrich Martin,b   Andreas Kirschning*a  and  Gerald Dräger*a  

* Corresponding authors

a Institut für Organische Chemie and Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover, Schneiderberg 1b, Hannover, Germany
E-mail: andreas.kirschning@oci.uni-hannover.de
Fax: +49 (0)511-7623011
Tel: +49 (0)511-7624614

b Hannover Medical School (MHH), Department of Cardiac, Thoracic, Transplantation and Vascular surgery (HTTG), Leibniz research laboratories for biotechnology and artificial organs (LEBAO), Carl-Neuberg-Str. 1, Hannover, Germany

Abstract

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

Graphical abstract: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C1OB05332A
Article type
Paper
Submitted
02 Mar 2011
Accepted
26 Apr 2011
First published
27 Apr 2011

Org. Biomol. Chem., 2011,9, 5503-5510

Permissions

Request permissions

A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

J. Paleček, R. Zweigerdt, R. Olmer, U. Martin, A. Kirschning and G. Dräger, Org. Biomol. Chem., 2011, 9, 5503 DOI: 10.1039/C1OB05332A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements