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Issue 15, 2011
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A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

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Abstract

A practical synthesis of the Rho-Kinase inhibitor Y-27632 and two new fluoro derivatives was achieved in seven steps and with a good overall yield of 45% starting from commercially available (R)-1-phenylethylamine. Compared to Y-27632 the new fluoro derivatives showed reduced or no effect on hPSC vitality and expansion after dissociation in human pluripotent stem cells.

Graphical abstract: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

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Publication details

The article was received on 02 Mar 2011, accepted on 26 Apr 2011 and first published on 27 Apr 2011


Article type: Paper
DOI: 10.1039/C1OB05332A
Citation: Org. Biomol. Chem., 2011,9, 5503-5510
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    A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and their evaluation in human pluripotent stem cells

    J. Paleček, R. Zweigerdt, R. Olmer, U. Martin, A. Kirschning and G. Dräger, Org. Biomol. Chem., 2011, 9, 5503
    DOI: 10.1039/C1OB05332A

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