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Issue 11, 2011
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Synthesis of novel chromene scaffolds for adenosine receptors

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Abstract

A one-pot procedure was developed for the synthesis of novel 3-[amino(methoxy)methylene]-2-oxo-3,4-dihydro-2H-chromen-4-yl)-3-cyanoacetamides and chromeno[3,4-c]pyridine-1-carbonitriles from the reaction of 2-oxo-2H-chromene-3-carbonitriles and cyanoacetamides. These chromene derivatives were identified as new scaffolds for adenosine receptors and the hits 3a, 3c, 5a, and 5b were found.

Graphical abstract: Synthesis of novel chromene scaffolds for adenosine receptors

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Publication details

The article was received on 24 Feb 2011, accepted on 25 Mar 2011 and first published on 20 Apr 2011


Article type: Paper
DOI: 10.1039/C1OB05305A
Citation: Org. Biomol. Chem., 2011,9, 4242-4249
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    Synthesis of novel chromene scaffolds for adenosine receptors

    M. Costa, F. Areias, M. Castro, J. Brea, M. I. Loza and F. Proença, Org. Biomol. Chem., 2011, 9, 4242
    DOI: 10.1039/C1OB05305A

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