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Issue 12, 2011
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Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

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Abstract

Two new peloruside congeners (3 and 4) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli. Small-scale reactions on peloruside A (1) have been performed, which along with the isolation of 3 and 4, give further insight into the bioactive pharmacophore of 1.

Graphical abstract: Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

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Publication details

The article was received on 06 Dec 2010, accepted on 21 Mar 2011 and first published on 23 Mar 2011


Article type: Paper
DOI: 10.1039/C0OB01127D
Citation: Org. Biomol. Chem., 2011,9, 4456-4466
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    Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

    A. J. Singh, M. Razzak, P. Teesdale-Spittle, T. N. Gaitanos, A. Wilmes, I. Paterson, J. M. Goodman, J. H. Miller and P. T. Northcote, Org. Biomol. Chem., 2011, 9, 4456
    DOI: 10.1039/C0OB01127D

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