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Issue 7, 2011
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Supramolecular hydrogels based on short peptides linked with conformational switch

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Abstract

Short peptides appropriately linked with an azobenzene conformational switch were found to be motif and pH dependant supramolecular hydrogelators. The hydrogelation properties of the short peptides linked with the conformational switch were studied in detail with respect to dependence on amino acid residue, pH and salt effect. The presence of amino acids with aromatic side chains such as Phe and Tyr was found to be favorable for the short peptides to gel water at an appropriate pH range. Cationic amino acid residues such as Arg and Lys in the short peptides were found to be unfavorable for hydrogelation. pH and salt effect were also found to be important factors for the hydrogelation properties of the short peptides. A series of short peptides with bioactive sequences were linked with the conformational switch and their hydrogelation properties were investigated. Photoresponsive supramolecular hydrogels were realized based on the E-/Z- transition of the conformational switch upon light irradiation. Proper combination of amino acid residues in the short peptides resulted in smart supramolecular hydrogels with responses to multiple stimuli.

Graphical abstract: Supramolecular hydrogels based on short peptides linked with conformational switch

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Publication details

The article was received on 20 Nov 2010, accepted on 14 Dec 2010 and first published on 07 Feb 2011


Article type: Paper
DOI: 10.1039/C0OB01057J
Citation: Org. Biomol. Chem., 2011,9, 2149-2155
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    Supramolecular hydrogels based on short peptides linked with conformational switch

    Y. Huang, Z. Qiu, Y. Xu, J. Shi, H. Lin and Y. Zhang, Org. Biomol. Chem., 2011, 9, 2149
    DOI: 10.1039/C0OB01057J

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