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Issue 7, 2011
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Aggregation behaviour of peptidepolymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization

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Abstract

A series of peptides with an alternating sequence of alkoxyamine conjugated lysine and glycine residues were synthesized by classical solution phase peptide coupling. The resulting peptides containing up to eight alkoxyamine moieties were used as initiators in nitroxide-mediated polymerization (NMP) to obtain peptidepolymer conjugates with well defined linear peptide backbones and a defined number of polymeric side chains. Polymerization of styrene and N-isopropylacrylamide (NIPAM) occurred in a highly controlled fashion. Molecular weight and polydispersity index (PDI) were determined by gel permeation chromatography (GPC). Aggregation behaviour of these hybrid materials was investigated by dynamic light scattering (DLS) and atomic force microscopy (AFM). Depending on composition, number and length of the polymer side chains, the conjugates aggregate to different topologies. Whereas peptidepolystyrene conjugates may aggregate to so called honeycomb structures, peptide–poly-N-isopropylacrylamide conjugates show differentiated aggregation behaviour.

Graphical abstract: Aggregation behaviour of peptide–polymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization

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Publication details

The article was received on 18 Nov 2010, accepted on 07 Jan 2011 and first published on 14 Feb 2011


Article type: Paper
DOI: 10.1039/C0OB01047B
Citation: Org. Biomol. Chem., 2011,9, 2403-2412
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    Aggregation behaviour of peptidepolymer conjugates containing linear peptide backbones and multiple polymer side chains prepared by nitroxide-mediated radical polymerization

    M. Möller, C. Hentschel, L. Chi and A. Studer, Org. Biomol. Chem., 2011, 9, 2403
    DOI: 10.1039/C0OB01047B

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