Jump to main content
Jump to site search

Issue 10, 2011
Previous Article Next Article

Carbohydrate chemistry in drug discovery

Author affiliations

Abstract

The multitude of roles that carbohydrates and their glyco-conjugates play in biological processes has stimulated great interest in determining the nature of their interactions in both normal and diseased states. Manipulating such interactions will provide leads for drug discovery. Of the major classes of biomolecule, carbohydrates are the most structurally diverse. This hetereogeneity makes isolation of pure samples, and in sufficient amounts, from biological sources extremely difficult. Chemical synthesis offers the advantage of producing pure and structurally defined oligosaccharides for biological investigations. Although the complex nature of carbohydrates means that this is challenging, recent advances in the field have facilitated access to these molecules. The synthesis and isolation of oligosaccharides combined with progress in glycoarray technology have aided the identification of new carbohydrate-binding drug targets. This review aims to provide an overview of the latest advancements in carbohydrate chemistry and the role of these complex molecules in drug discovery, focusing particularly on synthetic methodologies, glycosaminoglycans, glycoprotein synthesis and vaccine development over the last few years.

Graphical abstract: Carbohydrate chemistry in drug discovery

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 11 Nov 2010 and first published on 16 Mar 2011


Article type: Perspective
DOI: 10.1039/C0OB01017K
Citation: Org. Biomol. Chem., 2011,9, 3598-3610
  •   Request permissions

    Carbohydrate chemistry in drug discovery

    M. C. Galan, D. Benito-Alifonso and G. M. Watt, Org. Biomol. Chem., 2011, 9, 3598
    DOI: 10.1039/C0OB01017K

Search articles by author