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Department of Chemistry, Indian Institute of Technology Bombay, India
E-mail: chhbsia@chem.iitb.ac.in
; Fax: +91 022 2572 3480
; Tel: +91 022 2576 7190
b
Department of Chemistry, Howard University, USA
Org. Biomol. Chem., 2011,9, 581-587
DOI:
10.1039/C0OB00038H
Received
23 Apr 2010,
Accepted
16 Sep 2010
First published online
04 Nov 2010
Syntheses of several diorganodiselenides and, in particular, a seven-membered cyclic seleninate ester derived from 2-phenoxyethanol are described. The seleninate ester was obtained from allyl (2-(2-hydroxyethoxy)phenyl) selenide through a series of oxidation and [2,3] sigmatropic rearrangement steps. The ester exhibits good GPx-like activity in the coupled reductase assay.
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Organic & Biomolecular Chemistry
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