Issue 21, 2011
From the journal:

Organic & Biomolecular Chemistry

Proteinassembly directed by synthetic molecular recognition motifs†

Mingming Maa  and  Dennis Bong*a  

* Corresponding authors

a Department of Chemistry, The Ohio State University, Columbus, USA
E-mail: bong@chem.osu.edu
Fax: +1 614-292-1685
Tel: +1 614-247-8404

Abstract

Tris-functionalized cyanuric acid (TCA) and melamine (TM) selectively recognize each other in aqueous solution with 1 : 1 stoichiometry. We have coupled biotin to TCA and TM to allow pseudo-tetrahedral display of TCA and TM on streptavidin through biotin–ligand binding. Synthetic cyanuric acid/melamine recognition is found to drive selective protein–protein assembly.

Graphical abstract: Protein assembly directed by synthetic molecular recognition motifs

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Article information

DOI
https://doi.org/10.1039/C1OB05998J
Article type
Communication
Submitted
21 Jun 2011
Accepted
12 Aug 2011
First published
15 Aug 2011

Org. Biomol. Chem., 2011,9, 7296-7299

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Protein assembly directed by synthetic molecular recognition motifs

M. Ma and D. Bong, Org. Biomol. Chem., 2011, 9, 7296 DOI: 10.1039/C1OB05998J

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