Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda; Hiroyuki Yanagisawa; Akiko Nakamura; Dan Ohtan Wang; Mizue Yuki; Akimitsu Okamoto

doi:10.1039/C1OB05252G

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Organic & Biomolecular Chemistry

Issue 11, 2011

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Hybridization-sensitive fluorescence control in the near-infrared wavelength range

Shuji Ikeda , Hiroyuki Yanagisawa , Akiko Nakamura , Dan Ohtan Wang , Mizue Yuki and Akimitsu Okamoto

Org. Biomol. Chem., 2011,9, 4199-4204

DOI: 10.1039/C1OB05252G
Received 17 Feb 2011, Accepted 25 Mar 2011
First published on the web 25 Mar 2011

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Abstract
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A series of near-infrared fluorescent probes were designed based on the concept of emission control caused by interdye excitonic interaction. The fluorescent probes showed very weak emission in the unhybridized state, whereas they emitted near-infrared fluorescence after hybridization with the complementary nucleic acid. The hybridization-dependent switching of fluorescence emission made it possible to monitor mRNA in human cells in the range of near-infrared wavelengths.