Jump to main content
Jump to site search

Issue 11, 2011
Previous Article Next Article

Readily available hydrogen bond catalysts for the asymmetric transfer hydrogenation of nitroolefins

Author affiliations

Abstract

This paper focuses on readily accessible thiourea hydrogen bond catalysts derived from amino acids, whose steric and electronic features are modulated by their degree of substitution at the carbinol carbon center. These catalysts were applied in the asymmetric transfer hydrogenation of nitroolefins furnishing the chiral products in up to 99% yield and 86% enantiomeric excess. The proposed catalyst's mode of action is supported by mechanistic investigations.

Graphical abstract: Readily available hydrogen bond catalysts for the asymmetric transfer hydrogenation of nitroolefins

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Jan 2011, accepted on 14 Mar 2011 and first published on 14 Apr 2011


Article type: Paper
DOI: 10.1039/C1OB05059A
Citation: Org. Biomol. Chem., 2011,9, 4323-4327
  •   Request permissions

    Readily available hydrogen bond catalysts for the asymmetric transfer hydrogenation of nitroolefins

    J. F. Schneider, M. B. Lauber, V. Muhr, D. Kratzer and J. Paradies, Org. Biomol. Chem., 2011, 9, 4323
    DOI: 10.1039/C1OB05059A

Search articles by author

Spotlight

Advertisements