Issue 8, 2011
From the journal:

Organic & Biomolecular Chemistry

Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations†

Yang Liu,a   Liping Huang,a   Fuchun Xie,a   Xuxing Chena  and  Youhong Hu*a  

* Corresponding authors

a State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, 555 Zu Chong Zhi Road, Shanghai, China
E-mail: yhhu@mail.shcnc.ac.cn
Fax: +86-21-5080-5896
Tel: +86-21-5080-5896

Abstract

A base-promoted, microwave-assisted one-pot tandem reaction from simple 3-(1-alkynyl)chromones with 2-halobenzylic nitriles (esters or amides) for the synthesis of novel functional polycyclic chromenones has been developed. This tandem process involves multiple reactions, such as Michael addition and double cyclizations without a transition metal catalyst.

Graphical abstract: Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations

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Article information

DOI
https://doi.org/10.1039/C0OB01000F
Article type
Paper
Submitted
09 Nov 2010
Accepted
01 Feb 2011
First published
03 Feb 2011

Org. Biomol. Chem., 2011,9, 2680-2684

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Synthesis of novel functional polycyclic chromones through Michael addition and double cyclizations

Y. Liu, L. Huang, F. Xie, X. Chen and Y. Hu, Org. Biomol. Chem., 2011, 9, 2680 DOI: 10.1039/C0OB01000F

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