Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 4, 2011
Previous Article Next Article

Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Author affiliations

Abstract

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

Graphical abstract: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 30 Oct 2010, accepted on 24 Nov 2010 and first published on 16 Dec 2010


Article type: Communication
DOI: 10.1039/C0OB00957A
Citation: Org. Biomol. Chem., 2011,9, 980-983
  •   Request permissions

    Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

    M. Hu, J. Fan, H. Li, K. Song, S. Wang, G. Cheng and X. Peng, Org. Biomol. Chem., 2011, 9, 980
    DOI: 10.1039/C0OB00957A

Search articles by author