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Issue 4, 2011
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Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

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Abstract

A novel molecule T1 with efficient intramolecular charge transfer was designed as a fluorescent chemodosimeter for cysteine (Cys) and homocysteine (Hcy). Upon addition of Cys/Hcy, T1 exhibited greatly enhanced fluorescence intensity as well as a large absorption peak shift (70 nm), and can be used for bioimaging of Cys/Hcy in living cells and detection in human plasma by visual color change. The detection mechanism was proved by 1H NMR, mass spectrometry analysis and Gaussian calculations.

Graphical abstract: Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

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Publication details

The article was received on 30 Oct 2010, accepted on 24 Nov 2010 and first published on 16 Dec 2010


Article type: Communication
DOI: 10.1039/C0OB00957A
Citation: Org. Biomol. Chem., 2011,9, 980-983
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    Fluorescent chemodosimeter for Cys/Hcy with a large absorption shift and imaging in living cells

    M. Hu, J. Fan, H. Li, K. Song, S. Wang, G. Cheng and X. Peng, Org. Biomol. Chem., 2011, 9, 980
    DOI: 10.1039/C0OB00957A

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